Shigeto Tohma Selected Research

Peptides (Polypeptides)

1/2015	Early therapeutic intervention with methotrexate prevents the development of rheumatoid arthritis in patients with recent-onset undifferentiated arthritis: A prospective cohort study.
2/2013	Baseline anti-citrullinated peptide antibody (ACPA) titers and serum interleukin-6 (IL-6) levels possibly predict progression of bone destruction in early stages of rheumatoid arthritis (ERA).
12/2010	Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset: a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.
6/2007	Comprehensive investigation of disease-specific short peptides in sera from patients with systemic sclerosis: complement C3f-des-arginine, detected predominantly in systemic sclerosis sera, enhances proliferation of vascular endothelial cells.
8/2003	Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.

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Shigeto Tohma Research Topics

Disease

62	Rheumatoid Arthritis 09/2022 - 08/2003
14	Infections 01/2022 - 01/2009
13	Interstitial Lung Diseases (Interstitial Lung Disease) 01/2022 - 01/2012
11	Autoimmune Diseases (Autoimmune Disease) 01/2022 - 02/2010
10	Rheumatic Diseases (Rheumatism) 04/2018 - 07/2006
7	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2018 - 01/2010
4	Neoplasms (Cancer) 05/2021 - 07/2007
4	Tuberculosis (Tuberculoses) 04/2021 - 12/2006
4	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 01/2021 - 01/2019
4	Systemic Scleroderma (Systemic Sclerosis) 11/2020 - 06/2007
4	Lung Diseases (Lung Disease) 02/2019 - 01/2016
4	Vasculitis (Vasculitides) 01/2019 - 12/2004
4	Pneumonia (Pneumonitis) 12/2017 - 01/2013
3	Idiopathic Pulmonary Fibrosis 01/2022 - 12/2018
3	Asthma (Bronchial Asthma) 01/2022 - 09/2019
3	Dermatomyositis (Dermatopolymyositis) 07/2020 - 01/2012
3	Collagen Diseases (Collagen Disease) 01/2019 - 02/2013
3	Granulomatosis with Polyangiitis (Wegener's Granulomatosis) 01/2018 - 01/2013
3	Hypersensitivity (Allergy) 11/2015 - 01/2013
2	Pain (Aches) 09/2022 - 06/2018
2	Autoimmune Hepatitis 01/2021 - 01/2017
2	Myositis (Idiopathic Inflammatory Myopathies) 07/2020 - 09/2011
2	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis 01/2018 - 01/2016
2	Lymphoma (Lymphomas) 04/2015 - 07/2007
2	Vascular Diseases (Vascular Disease) 01/2015 - 01/2015
1	Mixed Connective Tissue Disease (MCTD) 01/2022
1	COVID-19 01/2022
1	Latent Infection 04/2021
1	Latent Tuberculosis 04/2021
1	Polymyositis 07/2020
1	Inflammation (Inflammations) 09/2019
1	Airway Remodeling 09/2019

Drug/Important Bio-Agent (IBA)

13	Pharmaceutical PreparationsIBA 05/2021 - 10/2006
10	HLA-DRB1 Chains (HLA DRB1)IBA 01/2022 - 01/2013
10	Methotrexate (Mexate)FDA LinkGeneric 02/2019 - 07/2007
10	Biological ProductsIBA 04/2018 - 12/2006
9	AntibodiesIBA 01/2022 - 12/2006
7	C-Reactive ProteinIBA 09/2022 - 10/2006
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 12/2004
7	HLA Antigens (Human Leukocyte Antigens)IBA 07/2020 - 01/2012
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 12/2006
7	Antirheumatic Agents (DMARD)IBA 02/2016 - 07/2011
6	Adrenal Cortex Hormones (Corticosteroids)IBA 09/2022 - 12/2011
6	tocilizumab (atlizumab)FDA Link 01/2015 - 01/2009
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 01/2010
5	Interleukin-6 (Interleukin 6)IBA 01/2020 - 01/2009
5	GlucocorticoidsIBA 02/2019 - 01/2013
5	Peptides (Polypeptides)IBA 01/2015 - 08/2003
4	Rheumatoid FactorIBA 01/2022 - 10/2006
4	CytokinesIBA 01/2022 - 01/2020
4	Immunoglobulin G (IgG)IBA 01/2022 - 12/2006
4	Abatacept (Orencia)FDA Link 05/2021 - 07/2013
4	GoldIBA 04/2021 - 01/2014
4	Tumor Necrosis Factor InhibitorsIBA 02/2019 - 07/2011
3	1- hydroxy- 5,8- bis(2- ((2- hydroxyethyl)amino)ethylamino)- 9,10- anthracenedioneIBA 09/2022 - 07/2016
3	Anti-Citrullinated Protein AntibodiesIBA 01/2022 - 12/2006
3	Tacrolimus (Prograf)FDA LinkGeneric 05/2021 - 04/2015
3	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/2019 - 01/2016
3	3' Untranslated Regions (3' UTR)IBA 01/2018 - 03/2011
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 01/2013
3	SteroidsIBA 12/2017 - 01/2012
3	23-valent pneumococcal capsular polysaccharide vaccineIBA 01/2017 - 06/2015
3	Polysaccharides (Glycans)IBA 12/2015 - 06/2015
3	AutoantibodiesIBA 01/2015 - 08/2003
2	Prostaglandins AIBA 09/2022 - 06/2018
2	N-phthaloylglutamic acidIBA 09/2022 - 06/2018
2	Immunoglobulin A (IgA)IBA 01/2022 - 03/2018
2	Immunoglobulin M (IgM)IBA 01/2022 - 01/2017
2	RibonucleoproteinsIBA 01/2022 - 01/2013
2	Monoclonal AntibodiesIBA 01/2022 - 11/2020
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 04/2021 - 01/2020
2	AntigensIBA 01/2020 - 03/2018
2	Sulfasalazine (Azulfidine)FDA LinkGeneric 02/2019 - 02/2016
2	Peroxidase (Myeloperoxidase)IBA 01/2019 - 01/2016
2	HLA-DPB1 antigen (HLA DPB1)IBA 01/2018 - 01/2013
2	HLA-A31 antigenIBA 12/2017 - 01/2013
2	VaccinesIBA 01/2017 - 12/2015
2	EnzymesIBA 01/2015 - 08/2003
2	CollagenIBA 01/2015 - 01/2015
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2013 - 12/2011
2	Immunosuppressive Agents (Immunosuppressants)IBA 01/2013 - 01/2012
2	cyclic citrullinated peptideIBA 12/2006 - 07/2006
2	AutoantigensIBA 01/2006 - 08/2003
1	cyclo(Arg-Pro) (CI 4)IBA 01/2022
1	HLA-DRB1*04:01 antigenIBA 01/2022
1	benralizumabIBA 01/2022
1	MitogensIBA 01/2022
1	Interleukin-5 Receptors (Interleukin 5 Receptor)IBA 01/2022
1	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 01/2021
1	mepolizumabIBA 11/2020
1	poly(dG-dA)n.poly(dC-dT)n (((GA)n))IBA 11/2020
1	Interleukin-2 (IL2)IBA 01/2020
1	Interleukin-8 (Interleukin 8)IBA 01/2020
1	LeptinIBA 09/2019
1	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 01/2019
1	NF-kappa B (NF-kB)IBA 01/2019
1	P-2 (P 2)IBA 12/2018

Therapy/Procedure

10	Therapeutics 11/2020 - 07/2011
2	Orthopedic Procedures 11/2017 - 06/2010
1	Transitional Care 11/2018